Molecular Pathogens, 2025, Vol.16, No.1, 27-35 http://microbescipublisher.com/index.php/mp 33 quickly screen disease-resistant varieties in breeding. There are also some studies combining gene expression and metabolite analysis and found that activation of metabolic pathways such as styrene pathway and terpene compound synthesis can also help sweet potatoes resist nematodes and other pathogens. Finding these resistance genes and pathways will be very useful for future sweet potato cultivation. If we can understand how these genes work, we can select more disease-resistant sweet potato varieties in breeding. This not only reduces the use of pesticides, but also increases yields and makes agriculture more sustainable. Using molecular markers in breeding can help find the target plant faster and help us develop sweet potato varieties that can resist multiple diseases at the same time. This is very helpful for ensuring food security and the development of green agriculture. Future research should go further to verify how these disease-resistant genes work. We can also use gene editing technology, such as CRISPR/Cas9, to modify some key genes and improve the resistance of sweet potatoes. It is also necessary to study the interaction between sweet potatoes and various pathogens more deeply, and strive to find some broad-spectrum resistance strategies. In addition, if more genetic resources of sweet potatoes can be collected or compared with other crops for comparison and analysis, some common anti-disease mechanisms may be discovered. These achievements can help us "borrow" our disease resistance characteristics into different crops and further improve our overall disease resistance. Acknowledgments Thanks Dr. W. Zhang from the Institute of Life Science of Jiyang College of Zhejiang A&F University for this assistance with the serious reading and helpful discussions during the course of this work. Conflict of Interest Disclosure The author affirms that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Armstrong M., Vossen J., Lim T., Hutten R., Xu J., Strachan S., Harrower B., Champouret N., Gilroy E., and Hein I., 2018, Tracking disease resistance deployment in potato breeding by enrichment sequencing, Plant Biotechnology Journal, 17: 540-549. https://doi.org/10.1111/pbi.12997 Cao W., Gan L., Shang K., Wang C., Song Y., Liu H., Zhou S., and Zhu C., 2020, Global transcriptome analyses reveal the molecular signatures in the early response of potato (Solanum tuberosumL.) to Phytophthora infestans, Ralstonia solanacearumand potato virus Y infection, Planta, 252: 1-13. https://doi.org/10.1007/s00425-020-03471-6 Chowdhury R.N., Lasky D., Karki H., Zhang Z., Goyer A., Halterman D., and Rakotondrafara A.M., 2019, HCPro suppression of callose deposition contributes to strain specific resistance against potato virus Y, Phytopathology, 110(1): 164-173. https://doi.org/10.1094/phyto-07-19-0229-fi Deng X., Peng X., Zhu F., Chen Y., Zhu T., Qin S., Xi D., and Lin H., 2015, A critical domain of sweet potato chlorotic fleck virus nucleotide-binding protein (NaBp) for RNA silencing suppression nuclear localization and viral pathogenesis, Molecular Plant Pathology, 16(4): 365-375. https://doi.org/10.1111/mpp.12186 Duan Y., Duan S., Armstrong M., Xu J., Zheng J., Hu J., Chen X., Hein I., Li G., and Jin L., 2019, Comparative transcriptome profiling reveals compatible and incompatible patterns of potato toward Phytophthora infestans, G3, 10: 623-634. https://doi.org/10.1534/g3.119.400818 Gupta P., Balyan H., and Gautam T., 2021, SWEETgenes and TAL effectors for disease resistance in plants: present status and future prospects, Molecular Plant Pathology, 22: 1014-1026. https://doi.org/10.1111/mpp.13075 Kiemo F.W., Salamon P., Tóth Z., and Szabó Z., 2024, Defense strategies against sweet potato chlorotic stunt and pakakuy virus coinfection unraveled, Crop Science, 64(6): 3438-3460. https://doi.org/10.1002/csc2.21392 Kim T.H., Kim S., Park W., Woo K.S., Lee K., Chung M.N., Lee Y.H., Lee H.U., Lee K., Nam S., Jo H., and Lee J., 2023, Genome-wide association study to identify novel loci and genes for Fusarium root rot resistance in sweet potato using genotyping-by-sequencing, Frontiers in Plant Science, 14: 1251157. https://doi.org/10.3389/fpls.2023.1251157
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