Molecular Pathogens, 2025, Vol.16, No.1, 19-26 http://microbescipublisher.com/index.php/mp 23 problems, we need to continue to study how microorganisms affect each other. Some more reliable technologies should also be developed that can regulate the microbiota under various farmland conditions (Deng et al., 2022). 6 Case Studies in Microbiome-Driven Disease Suppression 6.1 Successful applications of biocontrol agents in wheat diseases Biocontrol bacteria use natural good bacteria in the soil and have shown great potential in wheat disease control. For example, scientists isolated a batch of bacteria from some soil that can inhibit disease. After these bacteria are mixed together, they have a significant inhibitory effect on Gaeumannomyces graminis var. tritici (Ggt). The study found that bacterial groups such as Serratia, Bacillus, and Acinetobacter can not only significantly reduce diseases, but also make wheat grow better in greenhouses and fields, which is better than using only one bacteria (Figure 2) (Méndez et al., 2021). In addition, some wheat varieties will naturally “recruit” specific rhizosphere bacteria. These microorganisms can help plants enhance resilience while reducing the harm caused by soil bacteria like Rhizoma. Figure 2 (A) Shoot and root biomass (g); (B) infection measured by blackening of roots 40 days after inoculation with 1% of Ggt and root biomass ratio; and (C) infection scale. Tukey’s test was used to compare treatment means; values followed by the same letter did not differ at p< 0.05 (n = 5). ** Denotes significant differences at p < 0.01 (Adopted from Méndez et al., 2021) 6.2 Field trials of engineered microbial consortia In order to verify whether these "transformed" microbiomes are really useful, scientists have conducted many field experiments. They used the bacterial populations screened from disease-inhibiting soil directly in the fields. It turned out that these good bacteria can indeed control Ggt and other pathogens, and the effect is good. The experiment also shows that the more microbial species, the more "cooperation" they will have, and the better the prevention effect will be. Moreover, long-term observations have found that if different crops are planted in
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