PGT_2026v17n2

Plant Gene and Trait 2026, Vol.17, No.2, 140-155 http://genbreedpublisher.com/index.php/pgt 154 Miao L.L., Zhou Q.M., Peng C., Liu Z.H., and Xiong L., 2019, Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview, Biomedicine and Pharmacotherapy, 117: 109060. https://doi.org/10.1016/j.biopha.2019.109060 Morais L.C., Koga A.Y., Klein T., Kist A.P., Oliveira M.M., Lipinski L.C., Beltrame F.L., and Ferrari P.C., 2023, Preliminary evaluation of wound healing potential of Leonurus japonicus Houtt. extracts, Chemistry and Biodiversity, 20: e202301243. https://doi.org/10.1002/cbdv.202301243 Oak M.K., Yang S., Choi G., and Song J.H., 2021, Comparative floral and pollen micromorphology of Leonurus japonicus and L. macranthus (Lamiaceae), Diversity, 13(11): 533. https://doi.org/10.3390/d13110533 Olennikov D.N., and Chirikova N.K., 2016, Caffeoylglucaric acids and other phenylpropanoids from Siberian Leonurus species, Chemistry of Natural Compounds, 52(5): 915-917. https://doi.org/10.1007/s10600-016-1814-1 Ou D., Fan Y., Zhou Q., Liu J., Zuo J., Wang F., Li L., Wang F., and Xiong L., 2025, Effect of Leonurus japonicus alkaloids on endometrial inflammation and its mechanisms, Journal of Ethnopharmacology, 342: 119432. https://doi.org/10.1016/j.jep.2025.119432 Qaderi M.M., Martel A.B., and Strugnell C.A., 2023, Environmental factors regulate plant secondary metabolites, Plants, 12(3): 447. https://doi.org/10.3390/plants12030447 Qu G.Z., Si C.L., and Wang M.H., 2006, Antioxidant constituents from Leonurus japonicus, Natural Product Sciences, 12(4): 197-200. Rabeh K., Hnini M., and Oubohssaine M., 2025, A comprehensive review of transcription factor-mediated regulation of secondary metabolites in plants under environmental stress, Stress Biology, 5(1): 15. https://doi.org/10.1007/s44154-024-00201-w Rojas-Sandoval J., and Acevedo-Rodríguez P., 2022, Leonurus japonicus (honeyweed), CABI Compendium. https://doi.org/10.1079/cpc.115194.20210102247 Rong W., Li J., Wang L., Luo S., Liang T., Qian X., Zhang X., Zhou Q., Zhu Y., and Zhu Q., 2022, Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy, Frontiers in Cardiovascular Medicine, 9: 969553. https://doi.org/10.3389/fcvm.2022.969553 Shang X., Pan H., Wang X., He H., and Li M., 2014, Leonurus japonicus Houtt.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine, Journal of Ethnopharmacology, 152(1): 14-32. https://doi.org/10.1016/j.jep.2013.12.052 Shi X., Chen G., Tan J., Li Z., Chen S., He J., Zhang L., and Xu H.X., 2022, Total alkaloid fraction of Leonurus japonicus Houtt. promotes angiogenesis and wound healing through SRC/MEK/ERK signaling pathway, Journal of Ethnopharmacology, 295: 115396. https://doi.org/10.1016/j.jep.2022.115396 Tan X., Wang X., Liu N., Li H., Liu Y., Zhang W., Shen Z.L., and Fan Y., 2025, Study on the therapeutic effect of Viola yedoensis and Leonurus japonicus on bovine endometritis, Journal of Animal Science, 103: skaf332. https://doi.org/10.1093/jas/skaf332 Wang C., Lv X., Liu W., Liu S., and Sun Z., 2020, Uncovering the pharmacological mechanism of motherwort (Leonurus japonicus Houtt.) for treating menstrual disorders: a systems pharmacology approach, Computational Biology and Chemistry, 89: 107384. https://doi.org/10.1016/j.compbiolchem.2020.107384 Wang J., Mao Y., Yang Y., Yang J., Jin B., Lin H., Tang J., Zeng W., Zhao Y., Gao W., Peters R.J., Guo J., Cui G., and Huang L., 2022a, Diterpene synthases from Leonurus japonicus elucidate epoxy-bridge formation of spiro-labdane diterpenoids, Plant Physiology, 189(1): 99-111. https://doi.org/10.1093/plphys/kiac056 Wang J.R., Song X.H., Li L.Y., Gao S.J., Shang F.H., Zhang X.M., and Yang Y., 2022b, Metabolomic analysis reveals dynamic changes in secondary metabolites of Sophora japonica L. during flower maturation, Frontiers in Plant Science, 13: 916410. https://doi.org/10.3389/fpls.2022.916410 Wang R., Li A., and Pang Z., 2025, Research progress on molecular mechanism and future perspectives of leonurine, Frontiers of Medicine, 19(4): 612-625. https://doi.org/10.1007/s11684-025-1138-2 Wang X., Zhang L., Yao G., Wang X., Yi S., Meng T., Meng D., Chen W., and Guo L., 2024, De novo chromosome-level genome assembly of Chinese motherwort (Leonurus japonicus), Scientific Data, 11(1): 55. https://doi.org/10.1038/s41597-023-02901-w Wang Y., Wang J., Garran T.A., Liu H., Lin H., Luo J., Yuan Q., Sun J., Dong W., and Guo L., 2023a, Genetic diversity and population divergence of Leonurus japonicus and its distribution dynamic changes from the last interglacial to the present in China, BMC Plant Biology, 23(1): 276. https://doi.org/10.1186/s12870-023-04284-x Wang Y., Xie L., Zhou X., Chen R., Zhao G., and Zhang F., 2023b, Prediction of the potentially suitable areas of Leonurus japonicus in China based on future climate change using the optimized MaxEnt model, Ecology and Evolution, 13(10): e10597. https://doi.org/10.1002/ece3.10597 Wei Q.H., Cao X.X., Xu D.F., Wang S.T., Zhang J.S., and Zhang H., 2023, Anti-inflammatory labdane diterpenoids from the aerial parts of Leonurus japonicus, Phytochemistry, 210: 113646. https://doi.org/10.1016/j.phytochem.2023.113646

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