PGT_2026v17n2

Plant Gene and Trait 2026, Vol.17, No.2, 140-155 http://genbreedpublisher.com/index.php/pgt 153 Chen C., Zhou L., Han Y., Wen J., Liu L., Liu Q., Peng C., and He Y., 2024b, Comprehensive analysis of the effects of climate change on the species distribution and active components of Leonurus japonicus Houtt., Industrial Crops and Products, 218: 119017. https://doi.org/10.1016/j.indcrop.2024.119017 Chen L., Zhao L., Bai Y., Hu R., and Si J., 2009, Genetic relationship analysis of different provenances of Leonurus japonicus by ISSR marker, China Journal of Chinese Materia Medica, 34(11): 1343-1345. Dou Y., Shu L., Jia X., Yao Y., Chen S., Xu Y., and Li Y., 2023, Rapid classification and identification of chemical constituents in Leonurus japonicus Houtt based on UPLC-Q-Orbitrap-MS combined with data post-processing techniques, Journal of Mass Spectrometry, 58(11): e4978. https://doi.org/10.1002/jms.4978 Du B.W., Zhang X.J., Shi N., Peng T., Gao J.B., Azimova B., Zhang R., Pu D., Wang C., Abduvaliev A., Rakhmanov A., Zhang G., Xiao W., and Wang F., 2020, Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), European Journal of Pharmacology, 879: 173154. https://doi.org/10.1016/j.ejphar.2020.173154 Elshafie H.S., Camele I., and Mohamed A.A., 2023, A comprehensive review on the biological, agricultural and pharmaceutical properties of secondary metabolites based-plant origin, International Journal of Molecular Sciences, 24(4): 3266. https://doi.org/10.3390/ijms24043266 Fan Y., Liu C., Wang F., Li L., Guo Y., Zhou Q., and Xiong L., 2024, Coumarins with different substituents from Leonurus japonicus have opposite effects on uterine smooth muscle, International Journal of Molecular Sciences, 25(18): 10162. https://doi.org/10.3390/ijms251810162 Gan M.L., Han L.F., Wang R.F., and Yang Z.C., 2019, Bioassay-guided isolation of an antimycobacterial compound from Leonurus japonicus Houtt., South African Journal of Botany, 121: 92-97. https://doi.org/10.1016/j.sajb.2018.10.025 Garran T.A., Ji R., Chen J.L., Xie D., Guo L., Huang L.Q., and Lai C.J.S., 2019, Elucidation of metabolite isomers of Leonurus japonicus and Leonurus cardiaca using discriminating metabolite isomerism strategy based on ultra-high performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry, Journal of Chromatography A, 1598: 141-153. https://doi.org/10.1016/j.chroma.2019.03.059 Guo T., Wang Q., Yi Y., Yin Z., Xu L., Yang F., Xu J., and Zhang M., 2025, Transcriptome analysis and genome-wide identification of WRKY gene family in Leonurus japonicus under drought stress, BMC Plant Biology, 25(1): 607. https://doi.org/10.1186/s12870-025-06606-7 Han Y., Wen J., Chen C., Zhou L., Zhang T., Feng W., Zhao Z., and He Y., 2024, Relevance of genetic and active ingredient content differences in Leonurus japonicus Houtt from different origins, Genetic Resources and Crop Evolution, 71(2): 801-810. https://doi.org/10.1007/s10722-023-01660-2 Hu Q., Li Q., Mao Y., Luo Y., Deng Z., and Zhang W., 2025, Assembly and analysis of the complete mitochondrial genome of Leonurus japonicus (Lamiaceae), Scientific Reports, 15(1): 13372. https://doi.org/10.1038/s41598-025-97594-z Huang L., Xu D.Q., Chen Y.Y., Yue S.J., and Tang Y.P., 2021, Leonurine, a potential drug for the treatment of cardiovascular system and central nervous system diseases, Brain and Behavior, 11(2): e01995. https://doi.org/10.1002/brb3.1995 Jan R., Asaf S., Numan M., Lubna, and Kim K.M., 2021, Plant secondary metabolite biosynthesis and transcriptional regulation in response to biotic and abiotic stress conditions, Agronomy, 11(5): 968. https://doi.org/10.3390/agronomy11050968 Li P., Yan M.X., Liu P., Yang D.J., He Z.K., Gao Y., Jiang Y., Kong Y., Zhong X., Wu S., Yang J., Wang H.X., Huang Y.B., Wang L., Chen X.Y., Hu Y.H., Zhao Q., and Xu P., 2024, Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution, Molecular Plant, 17(1): 158-177. https://doi.org/10.1016/j.molp.2023.11.003 Li Y., Kong D., Fu Y., Sussman M.R., and Wu H., 2020a, The effect of developmental and environmental factors on secondary metabolites in medicinal plants, Plant Physiology and Biochemistry, 148: 80-89. https://doi.org/10.1016/j.plaphy.2020.01.006 Li Y.Y., Lin Y.K., Liu X.H., Wang L., Yu M., Li D.J., Zhu Y.Z., and Du M.R., 2020b, Leonurine: From gynecologic medicine to pleiotropic agent, Chinese Journal of Integrative Medicine, 26(2): 152-160. https://doi.org/10.1007/s11655-019-3453-0 Liao L., Tang Y., Li B., Tang J., Xu H., Zhao K., and Zhang X., 2023, Stachydrine, a potential drug for the treatment of cardiovascular system and central nervous system diseases, Biomedicine and Pharmacotherapy, 161: 114489. https://doi.org/10.1016/j.biopha.2023.114489 Liu J., Peng C., Zhou Q.M., Guo L., Liu Z.H., and Xiong L., 2018, Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle, Phytochemistry, 145: 128-136. https://doi.org/10.1016/j.phytochem.2017.11.003 Malave M.J., Mendoza Z., Morillo M., Visbal T., Rondón M.E., and Carmona J., 2019, Composicion quimica y actividad biologica de los extractos de las partes aereas de Leonurus japonicus (Houtt.), Revista de la Facultad de Farmacia, 61(1): 25-36.

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