International Journal of Molecular Veterinary Research, 2025, Vol.15, No.1, 1-12 http://animalscipublisher.com/index.php/ijmvr 7 coevolutionary analysis in mammals could provide insights into the genetic susceptibility to infection and the progression of many diseases (Sironi et al., 2015). Figure 3 Phylogeny of putatively functional LILR genes in Carnivora (Adopted from Jelínek et al., 2023) Image caption: Coding sequences were compared to bovine, caprine, and human LILRs (Supplementary Data 1) by the Neighbor-Joining method and Tamura 3-parameter model in MEGA X. A bootstrap consensus tree is presented with branches reproduced in over 50% of 1000 replicates. The tree was rooted to the novel Ig-like gene sequences. Four Carnivora families are highlighted: Felidae (yellow)-the domestic cat (Felcat), jungle cat (Felcha), Bengal cat (Priben), fishing cat (Priviv), cheetah (Acijub), Geoffroy’s cat (Leogeo), Canada lynx (Lyncan), clouded leopard (Neoneb), lion (Panleo), tiger (Pantig); Canidae (green)-wolf (Canlup), domestic dog (Canfam), dingo (Candin), Tibetan sand fox (Vulfer), arctic fox (Vullag); Mustelidae (brown)-ermine (Muserm), European badger (Melmel), American mink (Neovis), Eurasian otter (Lutlut); and Otariidae (blue)-California sea lion (Zalcal) (Adopted from Jelínek et al., 2023) 8 Genomic Responses to Emerging Pathogens in Canids 8.1 Historical pathogen outbreaks and genomic signatures Historical pathogen outbreaks have left deep genomic signatures in canids, and these are signs of the evolutionary forces exerted by such pathogens. Comparative genomics has shown that immune genes are among the most
RkJQdWJsaXNoZXIy MjQ4ODYzNA==