Molecular Pathogens, 2025, Vol.16, No.2, 53-60 http://microbescipublisher.com/index.php/mp 53 Review and Progress Open Access Signaling Pathways in Potato’s Response to Phytopathogens Yinghua Chen Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China Corresponding email: yinghua.chen@jicat.org Molecular Pathogens, 2025, Vol.16, No.2 doi: 10.5376/mp.2025.16.0007 Received: 22 Feb., 2025 Accepted: 23 Mar., 2025 Published: 31 Mar., 2025 Copyright © 2025 Chen, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Chen Y.H., 2025, Signaling pathways in potato’s response to phytopathogens, Molecular Pathogens, 16(2): 53-60 (doi: 10.5376/mp.2025.16.0007) Abstract This study reviews the signaling pathways of potatoes to cope with plant pathogens, and focuses on the role of key signaling molecules such as salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) in regulating plant defense responses. By analyzing the interactions of signaling pathways and their regulatory role in resistance gene expression, the core role of the StMKK5-StSIPK module in enhancing resistance and the key function of reactive oxygen species (ROS) in signaling transmission is demonstrated. The research explores the application prospects of CRISPR/Cas9 technology in genome editing and the disease prevention effect of exogenous signaling molecules (such as SA) in actual agriculture, providing important theoretical basis and practical guidance for future potato disease-resistant breeding and agricultural applications. Keywords Signaling pathways; Salicylic acid; Disease resistance; Phytophthora infestans; Molecular breeding 1 Introduction Potatoes are a very important crop in the world. It can not only be used as a staple food, but also contains rich nutrition. Globally, it is the fourth largest food crop after rice, wheat and corn. It is critical to both food security and agricultural development (Wang et al., 2023). However, potato cultivation is often affected by various diseases. These diseases will not only reduce yield, but also affect quality. Late blight caused by Phytophthora infestans and bacterial blight caused by Ralstonia solanacearumare common and serious diseases that may cause great economic losses (Yang et al., 2020). To enhance potato’s disease resistance, we need to figure out how plants defend against pathogens through signaling pathways in the body. Ethylene, salicylic acid and jasmonic acid are several important signaling molecules that help plants fight bacteria (Yang et al., 2023). These signals will influence each other, forming a complex network that activates the plant’s defense mechanism (Zheng et al., 2020; Yang et al., 2024). For example, the StMKK5-StSIPK module in potatoes can activate salicylic acid and ethylene pathways, making it more resistant to late-birth pathogens. In addition, the MAPK signaling pathway is also important, which regulates immune responses and enhances resilience to adverse environments (Zaynab et al., 2021). This study mainly discusses several signaling pathways involved in potatoes when fighting bacteria, such as ethylene, salicylic acid, jasmonic acid and MAPK. We combine transcriptome and multiomic data from recent years to further understand their role in disease resistance. These studies help us to have a clearer understanding of how these signals work and can also provide some ideas for improving potatoes’ disease resistance. 2 Phytopathogens and Their Interaction with Potatoes 2.1 Common potato phytopathogens (e.g., Phytophthora infestans) Potatoes are often affected by a pathogen called Phytophthora infestans, which can cause a serious disease called late blight. This disease will cause a large reduction in potato yields and has become a major problem in potato cultivation around the world (Yu et al., 2024). Besides it, there are also common pathogens that are also troublesome, such as Ralstonia solanacearum, which causes bacterial blight, and Potato virus Y, which causes necrotic ring spots. These pathogens also affect yield and quality (Cao et al., 2020).
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