Molecular Pathogens, 2025, Vol.16, No.1, 10-18 http://microbescipublisher.com/index.php/mp 16 Figure 3 Synergistic coexistence and in vivo interaction of GbPP2C80 andGbWAKL14 in sea island cotton (excerpt from Zhao et al., 2024) Future research can develop in several directions: First, further study how plant hormones affect each other, especially the relationship between SL, ABA and JA. The second is to deeply understand the mechanism of action of lncRNA, find new regulatory targets, and provide ideas for genetic engineering. The third is to focus on studying genes such as GhLAC15 and GhWRKY1-like, and try to cultivate more disease-resistant cotton varieties. Fourth, apply the disease-resistant genes found in GWAS to actual breeding to accelerate the cultivation of disease-resistant varieties. In addition, exploring the role of melatonin in preventing disease in other crops may also expand its application scope. Overall, this study has made a lot of substantial progress in improving cotton’s resistance to fungal pathogens. By combining genetics, molecular biology and biochemical methods, researchers have found many key genes and mechanisms. These achievements not only help us cultivate stronger cotton, but also provide a reference for other crops to prevent and control similar diseases. Continuing to conduct in-depth research in these directions is very important for ensuring cotton yield and planting sustainability. Acknowledgments The authors sincerely thank Dr. Zhong J. from Cuixi Biotechnology Research Institute for his professional opinions, as well as two peer reviewers for their suggestions and colleagues for their help.
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