MP_2025v16n1

Molecular Pathogens, 2025, Vol.16, No.1, 10-18 http://microbescipublisher.com/index.php/mp 14 bacteria are called microbial antagonists, one of which is Bacillus cyclic GN03. Research has found that this bacteria can change the microbial environment at the roots of cotton, allowing the roots to grow better, the seedlings are stronger, and the disease resistance is stronger. The experimental chart shows that compared with untreated cotton seedlings, the C1 and C2 groups using GN03 performed better in stem height, stem thickness, root length, number of leaves and leaf area. The roots also grow denser and more dynamic (Figure 2) (Qin et al., 2021). Why is this happening? Probably because these bacteria can promote cotton synthesize auxin and cytokinin, and help roots absorb more nutrients. At the same time, they can also activate some genes related to disease resistance, making cotton’s “natural defense system” stronger. This bacterial “biological agent” can replace some chemical agents and is a more environmentally friendly and sustainable way to prevent diseases. Figure 2 Morphological characteristics and phenotypic changes of cotton seedlings 30 days after GN03 inoculation (Adopted from Qin et al., 2021) 6 Case Study: Comprehensive Measures to Enhance Cotton Resistance to Fusarium Wilt in Xinjiang, China 6.1 Research background and objectives In China, Xinjiang is the place where cotton is grown the most. However, there is also a headache here - cotton has Fusarium wilt. This disease is caused by Fusarium oxysporumf. sp. vasinfectum, which reduces yield and also leads to poor cotton quality (Man et al., 2022). Like Verticillium dahliae, this disease has always troubled people who grow cotton. This study is about finding ways to make cotton more resistant to disease, with the focus on

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