Journal of Vaccine Research, 2025, Vol.15, No.1, 34-44 http://medscipublisher.com/index.php/jvr 38 Figure 2 The genome of Dengue virus and structural schematic diagrams of DENV vaccine candidates (Adopted from Huang et al., 2023) Image caption: (A) The genome is approximately 11 000 kb in length and is an enveloped, positive-sense, single-stranded RNA virus, encoding three structural and seven nonstructural proteins; (B) Four structure diagrams of live attenuated vaccine candidates, distinguished by different colors; CYD-TDV takes YFV 17D as the backbone and replaces prM/E genes with four serotypes; The backbone of TAK-003 is a weakened DENV2 strain (PDK-53) that contains the prM/E parts of all serotypes; TV003/TV005 has deletions in the 3’ untranslated region. ChinDENV applies JEV vaccine strain SA14-14-2 as the backbone and substitutes the prM/E gene of DENV; (C) Two types of mRNA vaccine candidates using different strategies; DENV1-NS contains the NS3, NS4B, andNS5 genes; prM/E mRNA-LNP encodes the prM/E structural proteins; (D) The plasmids VR1012 of TVDV (DNA vaccine) contain prM/E genes of four serotypes of DENV; (E) Protein vaccine V180 consists of a truncated protein DEN-80E expressed by the Drosophila S2 cell line; (F) Inactivated vaccine DPIV contains four serotypes of attenuated DENV in primary dog kidney (PDK) cells (Adopted from Huang et al., 2023)
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