IJMMS_2025v15n6

International Journal of Molecular Medical Science, 2025, Vol.15, No.6, 253-262 http://medscipublisher.com/index.php/ijmms 260 Alfaris N., Waldrop S., Johnson V., Boaventura B., Kendrick K., and Stanford F., 2024, GLP-1 single dual and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review, eClinicalMedicine, 75: 102782. https://doi.org/10.1016/j.eclinm.2024.102782 Anderson J., 2020, Combining glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors to target multiple organ defects in type 2 diabetes, Diabetes Spectrum, 33: 165-174. https://doi.org/10.2337/ds19-0031 Aronne L., Hall K., Jakicic J., Leibel R., Lowe M., Rosenbaum M., and Klein S., 2021, Describing the weight‐reduced state: physiology behavior and interventions, Obesity, 29: S9-24. https://doi.org/10.1002/oby.23086 Bednarz K., Kowalczyk K., Cwynar M., Czapla D., Czarkowski W., Kmita D., Nowak A., and Madej P., 2022, The role of Glp-1 receptor agonists in insulin resistance with concomitant obesity treatment in polycystic ovary syndrome, International Journal of Molecular Sciences, 23(8): 4334. https://doi.org/10.3390/ijms23084334 Berg S., Stickle H., Rose S., and Nemec E., 2025, Discontinuing glucagon‐like peptide‐1 receptor agonists and body habitus: a systematic review and meta‐analysis, Obesity Reviews, 26: e13929. https://doi.org/10.1111/obr.13929 Budini B., Luo S., Tam M., Stead I., Lee A., Akrami A., Vidal-Puig A., and Park A., 2025, Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression, medRxiv, 9: 2025-06. https://doi.org/10.1101/2025.06.09.25328726 Fadel L., Thao G., Chitre T., Rojas E., Fricko M., Domingo V., Budginas B., Guerrero L., Ghatas M., Arani N., Tabatabai N., and Pemminati S., 2025, A system-based review on effects of glucagon-like peptide-1 receptor agonists: benefits vs risks, Cureus, 17(2): e78575. https://doi.org/10.7759/cureus.78575 Gourdy P., Darmon 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bioactive lipids and adipose tissue inflammation in insulin resistance, Nutrients, 12(5): 1305. https://doi.org/10.3390/nu12051305 Liu X., and Shu M., 2025, Application and mechanism of GLP-1 receptor agonists in the treatment of obesity complicated with type 2 diabetes mellitus, International Journal of Public Health and Medical Research, 3(3): 69-74. https://doi.org/10.62051/ijphmr.v3n3.08 Liu Y., Ruan B., Jiang H., Le S., Liu Y., Ao X., Huang Y., Shi X., Xue R., Fu X., and Wang S., 2023, The weight-loss effect of GLP-1RAs glucagon-like peptide-1 receptor agonists in non-diabetic individuals with overweight or obesity: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials, The American Journal of Clinical Nutrition, 118(3): 614-626. https://doi.org/10.1016/j.ajcnut.2023.04.017 Madsbad S., and Holst J., 2025, The promise of glucagon-like peptide 1 receptor agonists (GLP-1RA) for the treatment of obesity: a look at phase 2 and 3 pipelines, 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