International Journal of Clinical Case Reports, 2025, Vol.15, No.4, 171-181 http://medscipublisher.com/index.php/ijccr 171 Research Insight Open Access Personalized Dietary and Pharmacological Management of Hyperuricemia in Patients with Chronic Kidney Disease (CKD) Lihui Xu, Keyan Fang Traditional Chinese Medicine Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, China Corresponding author: keyan.fang@cuixi.org International Journal of Clinical Case Reports 2025, Vol.15, No.4 doi: 10.5376/ijccr.2025.15.0018 Received: 07 Jun., 2025 Accepted: 16 Jul., 2025 Published: 31 Jul., 2025 Copyright © 2025 Xu and Fang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Xu L.H., and Fang K.Y., 2025, Personalized dietary and pharmacological management of hyperuricemia in patients with chronic kidney disease (CKD), International Journal of Clinical Case Reports, 15(4): 171-181 (doi: 10.5376/ijccr.2025.15.0018) Abstract This study explored the pathogenesis of chronic kidney disease, different stages of disease development, and its impact on human metabolism. It focused on personalized nutritional support and treatment methods required at different stages. The main contents included controlling the intake of protein and electrolytes, adjusting medication regimens based on individual differences, and adopting combined treatment for comorbidities. This study also highlights the significant role of multidisciplinary team (MDT) collaboration in enhancing treatment compliance and outcomes, and explores the prospects of integrating precision medicine and digital health technologies for CKD management in the future. This study aims to effectively delay the deterioration of the disease and truly improve the quality of life of patients through the integration and continuous monitoring of multiple means. Keywords Chronic kidney disease (CKD); Personalized dietary management; Pharmacological therapy adjustment; Multidisciplinary team (MDT); Precision medicine 1 Introduction Chronic kidney disease (CKD) is a serious health problem worldwide, affecting approximately 800 million people globally, leading to a significant increase in morbidity and mortality. The number of CKD patients has been increasing year by year. The main reasons are population aging and the increasing number of patients with diabetes, hypertension and cardiovascular diseases. CKD not only impairs renal function, but also affects the balance of water, electrolytes and toxins in the body, exerting tremendous pressure on the public health system (Dαbek et al., 2023; Caturano et al., 2024; Hassan, 2024). Chronic kidney disease is a condition that gradually worsens. If not treated in time, it may progress to an advanced stage, at which point dialysis or kidney transplantation will be required. Patients with CKD have a higher possibility of complications such as hyperuricemia, cardiovascular diseases, metabolic acidosis and electrolyte imbalance Especially hyperuricemia, which is not only a common complication but also an independent risk factor for the aggravation of CKD, further increasing the risk of complications in the kidneys and cardiovascular system (Oh et al., 2019; Kielstein et al., 2020; Johnson et al., 2022; Yang et al., 2022). If there are concurrent diseases such as diabetes and hypertension, it will accelerate the progression of the disease and also make the treatment and management more complicated (Dαbek et al., 2023; Caturano et al., 2024; Wang, 2024). This study will explore the individual differences among CKD patients and the complexity of their concomitant diseases. In this case, personalized and comprehensive management approaches become extremely important. Uniform dietary and medication recommendations often fail to meet the diverse metabolic, genetic and socio-cultural needs of each patient, which may lead to poor treatment outcomes and make it difficult for patients to adhere. Personalized management approaches, such as customized dietary intervention, individualized medication regimens and multidisciplinary care, have been proven to help slow the development of CKD, improve the quality of life and reduce the risk of complications. Early collaborative intervention among nephrologists, nutritionists and pharmacists is crucial for improving treatment outcomes and addressing the dual challenges of hyperuricemia and chronic kidney disease.
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