IJCCR_2025v15n4

International Journal of Clinical Case Reports, 2025, Vol.15, No.4, 159-170 http://medscipublisher.com/index.php/ijccr 169 Oliveira R., Oliveira A., Cruz A., Ribeiro O., Afreixo V., and Pimentel F., 2024, Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factors, BMC Geriatrics, 24(1): 557. https://doi.org/10.1186/s12877-024-05135-6 Pazan F., and Wehling M., 2021, Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences, European Geriatric Medicine, 12: 443-452. https://doi.org/10.1007/s41999-021-00479-3 Quiñones A.R., Markwardt S., and Botoseneanu A., 2016, Multimorbidity combinations and disability in older adults, The Journals of Gerontology, Series A, Biological Sciences and Medical Sciences, 71(6): 823-830. https://doi.org/10.1093/gerona/glw035 Reeve J., Maden M., Hill R., Turk A., Mahtani K., Wong G., Lasserson D., Krska J., Mangin D., Byng R., Wallace E., and Ranson E., 2022, Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis, Health Technology Assessment, 26(32): 1. https://doi.org/10.3310/AAFO2475 Roncal-Belzunce V., Gutiérrez-Valencia M., Leache L., Saiz L., Bell J., Erviti J., and Martínez-Velilla N., 2024, Systematic review and meta-analysis on the effectiveness of multidisciplinary interventions to address polypharmacy in community-dwelling older adults, Ageing Research Reviews, 98: 102317. https://doi.org/10.1016/j.arr.2024.102317 Schneider J., Algharably E., Budnick A., Wenzel A., Dräger D., and Kreutz R., 2021, High prevalence of multimorbidity and polypharmacy in elderly patients with chronic pain receiving home care are associated with multiple medication-related problems, Frontiers in Pharmacology, 12: 686990. https://doi.org/10.3389/fphar.2021.686990 Sheikh-Taha M., and Asmar M., 2021, Polypharmacy and severe potential drug-drug interactions among older adults with cardiovascular disease in the United States, BMC Geriatrics, 21(1): 223. https://doi.org/10.1186/s12877-021-02183-0 Stafford G., Villén N., Roso-Llorach A., Troncoso-Mariño A., Monteagudo M., and Violán C., 2021, Combined multimorbidity and polypharmacy patterns in the elderly: a cross-sectional study in primary health care, International Journal of Environmental Research and Public Health, 18(17): 9216. https://doi.org/10.3390/ijerph18179216 Stewart D., Mair A., Wilson M., Kardas P., Lewek P., Alonso A., McIntosh J., and Maclure K., 2016, Guidance to manage inappropriate polypharmacy in older people: systematic review and future developments, Expert Opinion on Drug Safety, 16: 203-213. https://doi.org/10.1080/14740338.2017.1265503 Swarbrick C., Williams K., Evans B., Blake H., Poulton T., Nava S., Shah A., Martin P., Partridge J., and Moppett I., 2025, Characteristics of older patients undergoing surgery in the UK: SNAP-3, a snapshot observational study, British Journal of Anaesthesia, 134: 328-340. https://doi.org/10.1016/j.bja.2024.11.024 Taghy N., Cambon L., Cohen J., and Dussart C., 2020, Failure to reach a consensus in polypharmacy definition: an obstacle to measuring risks and impacts-results of a literature review, Therapeutics and Clinical Risk Management, 16: 57-73. https://doi.org/10.2147/TCRM.S214187 Tran N., Tung D., Nguyen V., Nguyen V., Nguyen T., and Nguyen T., 2025, Characteristics of multimorbidity in hospitalized elderly patients, VietNam Military Medical Unisversity, 50(4): 92-101. https://doi.org/10.56535/jmpm.v50i4.1091 Van Onna M., and Boonen A., 2022, Challenges in the management of older patients with inflammatory rheumatic diseases, Nature Reviews Rheumatology, 18(6): 326-334. https://doi.org/10.1038/s41584-022-00768-6 Veronese N., Stubbs B., Noale M., Solmi M., Pilotto A., Vaona A., Demurtas J., Mueller C., Huntley J., Crepaldi G., and Maggi S., 2017, Polypharmacy is associated with higher frailty risk in older people: an 8-year longitudinal cohort study, Journal of the American Medical Directors Association, 18(7): 624-628. https://doi.org/10.1016/j.jamda.2017.02.009 WastessonJ., Morin L., Tan E., and Johnell K., 2018, An update on the clinical consequences of polypharmacy in older adults: a narrative review, Expert Opinion on Drug Safety, 17: 1185-1196. https://doi.org/10.1080/14740338.2018.1546841 Wilfling D., Hinz A., and Steinhäuser J., 2020, Big data analysis techniques to address polypharmacy in patients-a scoping review, BMC Family Practice, 21(1): 180. https://doi.org/10.1186/s12875-020-01247-1 Wu Q., Feng X., Shen C., Liu Y., Yang S., and Su N., 2025, Global research trends of home pharmaceutical care: a bibliometric analysis via citespace, Frontiers in Medicine, 12: 1489720. https://doi.org/10.3389/fmed.2025.1489720 Zemedikun D., Gray L., Khunti K., Davies M., and Dhalwani N., 2018, Patterns of multimorbidity in middle-aged and older adults: an analysis of the UK biobank data, Mayo Clinic Proceedings, 93: 857-866. https://doi.org/10.1016/j.mayocp.2018.02.012 Zhao Y., Wang J., Zhu, X., Zhang X., Zhang Y., Zhang W., and Dong Y., 2023, Multimorbidity and polypharmacy in hospitalized older patients: a cross-sectional study, BMC Geriatrics, 23(1): 423. https://doi.org/10.1186/s12877-023-04109-4

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