Bioscience Evidence 2024, Vol.14, No.5, 227-237 http://bioscipublisher.com/index.php/be 235 The future of ASFV research lies in the continued integration of genomic and proteomic data to uncover novel therapeutic targets and develop effective antiviral strategies. The use of multi-omics approaches, combining proteomics, genomics, and transcriptomics, will be crucial in identifying mechanisms of resistance and potential drug targets. Additionally, the exploration of cross-cancer effects of circulating proteins and their modulation by lifestyle changes could provide new insights into the prevention and treatment of ASFV infections. As research progresses, the development of targeted therapies and vaccines will be essential in mitigating the impact of ASFV on the global swine population and preventing future outbreaks. Acknowledgments We sincerely thank our colleagues, for their professional advice and technical support on the manuscript of this study. Your knowledge and experience helped us solve many critical issues and facilitated the smooth progress of the study. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Alfonso P., Rivera J., Hernáez B., Alonso C., and Escribano J., 2004, Identification of cellular proteins modified in response to African swine fever virus infection by proteomics, Proteomics, 4(7): 2037-2046. https://doi.org/10.1002/pmic.200300742 Bisimwa P., Ishara L., Wasso D., Bantuzeko F., Tonui R., and Bwihangane A., 2021, Detection and genetic characterization of African swine fever virus (ASFV) in clinically infected pigs in two districts in South Kivu province, Democratic Republic Congo, Heliyon, 7(3): e06419. https://doi.org/10.1016/j.heliyon.2021.e06419 Butler G., and Overall C., 2009, Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting, Nature Reviews Drug Discovery, 8: 935-948. https://doi.org/10.1038/nrd2945 Chin W., Ang S., and Chu J., 2017, Recent advances in therapeutic recruitment of mammalian RNAi and bacterial CRISPR-Cas DNA interference pathways as emerging antiviral strategies, Drug discovery today, 22(1): 17-30. https://doi.org/10.1016/j.drudis.2016.08.008 Chu W., Prodromou R., Day K., Schneible J., Bacon K., Bowen J., Kilgore R., Catella C., Moore B., Mabe M., Alashoor K., Xu Y., Xiao Y., and Menegatti S., 2020, Peptides and pseudopeptide ligands: a powerful toolbox for the affinity purification of current and next-generation biotherapeutics, Journal of Chromatography A, 1635: 461632. https://doi.org/10.1016/j.chroma.2020.461632 Correia S., Moura P., Ventura S., Leitão A., and Parkhouse R., 2023, I329L: A dual action viral antagonist of TLR activation encoded by the African swine fever virus (ASFV), Viruses, 15(2): 445. https://doi.org/10.3390/v15020445 Correia S., Ventura S., and Parkhouse R., 2013, Identification and utility of innate immune system evasion mechanisms of ASFV, Virus Research, 173(1): 87-100. https://doi.org/10.1016/j.virusres.2012.10.013 Dixon L., Chapman D., Netherton C., and Upton C., 2013, African swine fever virus replication and genomics, Virus research, 173(1): 3-14. https://doi.org/10.1016/j.virusres.2012.10.020 Dolata K., Pei G., Netherton C., and Karger A., 2023, Functional landscape of African swine fever virus-host and virus-virus protein interactions, Viruses, 15(8): 1634. https://doi.org/10.3390/v15081634 Dowdy S., 2017, Overcoming cellular barriers for RNA therapeutics, Nature Biotechnology, 35: 222-229. https://doi.org/10.1038/nbt.3802 Galindo I., Garaigorta U., Lasala F., Cuesta-Geijo M., Bueno P., Gil C., Delgado R., Gastaminza P., and Alonso C., 2020, Antiviral drugs targeting endosomal membrane proteins inhibit distant animal and human pathogenic viruses, Antiviral Research, 186: 104990-104990. https://doi.org/10.1016/j.antiviral.2020.104990 Gallardo C., Sánchez E., Pérez-Núñez D., Nogal M., León P., Carrascosa Á., Nieto R., Soler A., Arias M., and Revilla Y., 2018, African swine fever virus (ASFV) protection mediated by NH/P68 and NH/P68 recombinant live-attenuated viruses, Vaccine, 36(19): 2694-2704. https://doi.org/10.1016/j.vaccine.2018.03.040 Gallardo C., Soler A., Nurmoja I., Cano-Gómez C., Cvetkova S., Frant M., Woźniakowski G., Simón A., Pérez C., Nieto R., and Arias M., 2021, Dynamics of African swine fever virus (ASFV) infection in domestic pigs infected with virulent, moderate virulent and attenuated genotype II ASFV European isolates, Transboundary and Emerging Diseases, 68(5): 2826-2841. https://doi.org/10.1111/tbed.14222
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