Animal Molecular Breeding 2024, Vol.14, No.4, 262-270 http://animalscipublisher.com/index.php/amb 266 individuals with desirable resistance traits. This can lead to the development of dog breeds that are more resilient to diseases, ultimately improving animal welfare and reducing the need for medical interventions (Izquierdo and Crujeiras, 2019). Figure 2 Overview of the integrative mapping approach to generate a dog reference epigenome (Adopted from Son et al., 2022) Image caption: (A) Diagram of 11 primary tissue types from beagle dogs sampled for the study. (B) Synopsis of next-generation sequencing (NGS) methods, data integration approaches, and analyses performed for the integrative profiling the dog epigenome. See also Methods. (C) Matrix of in-house generated NGS dataset quality from 11 primary tissue types, including information on RNA expression, defined epigenomic modifications, and DNA methylation. Normalized data integrity measures for each NGS sample profile [transcript integrity number for whole-transcriptome RNA-seq and relative strand cross-correlation coefficient (RSC) quality score for histone ChIP-seq and MBD-seq] are displayed. Two replicates per sampled tissue were profiled (Adopted from Son et al., 2022) 5.2 Personalized veterinary medicine based on epigenetic profiles The integration of epigenetic profiles into veterinary medicine can revolutionize the way diseases are diagnosed and treated in dogs. By analyzing the epigenetic modifications, such as DNA methylation patterns, veterinarians can gain insights into the underlying mechanisms of diseases and their progression. This personalized approach allows for the development of tailored treatment plans that consider the unique epigenetic makeup of each dog. For instance, understanding the epigenetic factors involved in insulin resistance can lead to more effective management strategies for conditions like diabetes, which are influenced by both genetic and environmental
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