Animal Molecular Breeding 2024, Vol.14, No.4, 262-270 http://animalscipublisher.com/index.php/amb 262 Research Insight Open Access Gene Expression Profiles in Heat-Stressed Dairy Cattle Zhaolin Wang , Xiaofang Lin 1 Tropical Animal Medicine Research Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572000, Hainan, China Corresponding author: 745457309@qq.com Animal Molecular Breeding, 2024, Vol.14, No.4 doi: 10.5376/amb.2024.14.0027 Received: 16 May, 2024 Accepted: 01 Jul., 2024 Published: 17 Jul., 2024 Copyright © 2024 Wang and Lin, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Wang Z.L., and Lin X.F., 2024, Gene expression profiles in heat-stressed dairy cattle, Animal Molecular Breeding, 14(4): 262-270 (doi: 10.5376/amb.2024.14.0027) Abstract This study investigates the significance of epigenetic markers, such as DNA methylation, histone modifications, and non-coding RNAs, in regulating disease resistance in dogs. A comparative analysis of disease-resistant and susceptible dog breeds highlights key epigenetic differences, shedding light on potential applications for enhancing disease resistance. Despite the technical and ethical challenges associated with using epigenetic data in breeding, the study underscores the long-term potential of epigenetic profiling for disease prevention and health monitoring in dogs. By identifying specific epigenetic markers, this study provides a foundation for improving canine breeding programs and personalized veterinary medicine. Keywords Canine health; Epigenetics; Disease resistance; DNA methylation; Veterinary medicine 1 Introduction Disease resistance in dogs is a critical area of veterinary research, as it directly impacts the health and well-being of companion animals. Various pathogens, including bacteria, viruses, and parasites, pose significant threats to canine health, leading to conditions such as antimicrobial resistance and susceptibility to diseases like leishmaniasis and hookworm infections (Tyson et al., 2021). Understanding the genetic and immunological factors that contribute to disease resistance can help in developing effective strategies for disease prevention and management in dogs (Vasconcelos et al., 2017). Epigenetics, the study of heritable changes in gene expression that do not involve changes to the underlying DNA sequence, plays a crucial role in disease resistance (Wegener et al., 2018). Epigenetic mechanisms, such as DNA methylation, histone modification, and non-coding RNA regulation, can influence how genes are expressed in response to environmental factors, including pathogen exposure (Wang et al., 2023). These modifications can affect the immune response and the ability of dogs to resist infections, making the identification of epigenetic markers a promising area for enhancing disease resistance (Gul et al., 2022). Identifying epigenetic markers associated with disease resistance in dogs has significant implications for veterinary medicine (Ceric et al., 2019). These markers can serve as biomarkers for early detection of susceptibility to diseases, allowing for timely interventions and personalized treatment plans. Moreover, understanding the epigenetic landscape can lead to the development of novel therapeutic strategies that target specific epigenetic modifications to enhance disease resistance (Islam et al., 2020). This approach can reduce the reliance on antibiotics and other treatments, thereby mitigating the risk of antimicrobial resistance (Mahfouz et al., 2020). This study identifies and evaluates current knowledge on epigenetic markers of disease resistance in dogs, highlighting the potential of epigenetic research to improve canine health and disease management, including examining genetic and epigenetic factors, the role of specific epigenetic mechanisms, and the implications of these findings for veterinary practice and future research, with the aim of aiding further exploration of epigenetic regulation of disease resistance in dogs and developing targeted health interventions.
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